Case – Leuprolide acetate-induced necrotic skin ulceration

Authors

  • W.C. Ian Janes Faculty of Medicine, Memorial University
  • Boluwaji Ogunyemi Faculty of Medicine, Memorial University
  • Matthew Andrews Department of Urology, Memorial University

DOI:

https://doi.org/10.5489/cuaj.8112

Keywords:

skin necrosis, leuprolide acetate, adverse reactions, injection

Abstract

Androgen deprivation therapy (ADT) has become a well-established modality in the management of locally advanced and metastatic prostate cancer.1 Leuprolide acetate, a synthetically derived gonadotropin-releasing hormone receptor (GnRHR ) agonist, is commonly used for ADT in men.2 Despite proven effectiveness, the administration of GnRHR agonists is associated with common adverse reactions, such as impotence, hot flashes, and fatigue. Injection site reactions have also been documented; however, these are infrequent, with the most common being localized pain.3,4 Herein, we report a case of necrotic skin ulceration following multiple administrations of intramuscular leuprolide acetate.

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Published

2022-10-25

How to Cite

Janes, W. I., Ogunyemi, B., & Andrews, M. (2022). Case – Leuprolide acetate-induced necrotic skin ulceration. Canadian Urological Association Journal, 17(3), E92–4. https://doi.org/10.5489/cuaj.8112

Issue

Vol. 17 No. 3 (2023): CUAJ March

Section

Residents' Room

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