Classification, diagnosis and treatment of ACTH-independent macronodular adrenal hyperplasia

Authors

  • Heng-Chuan Su Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  • Xin Huang Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  • Jun Dai Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  • Wen-long Zhou Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  • Bao-xing Huang Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  • Wan-li Cao Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  • Fu-Kang Sun Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

DOI:

https://doi.org/10.5489/cuaj.420

Keywords:

ACTH-independent macronodular adrenal hyperplasia, Adrenalectomy, Ketoconazole, Plasma cortisol

Abstract

ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a distinctive subtype of Cushing’s syndrome (CS), with different clinical manifestations according to the level of serum cortisol. Based on clinical manifestations and serum cortisol, we divide AIMAH into three types, subclinical AIMAH, clinical AIMAH and high-risk AIMAH, with varied treatment methods being adapted to different subtypes. At the same time, we describe 3 patients who represent these subtypes of this disease, and review some cases of AIMAH which have been previously reported in the English literature. To our knowledge, this is the first article discussing classification, diagnosis and treatment of this disease and should be useful for future therapy of AIMAH.

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Published

2013-09-10

How to Cite

Su, H.-C., Huang, X., Dai, J., Zhou, W.- long, Huang, B.- xing, Cao, W.- li, & Sun, F.-K. (2013). Classification, diagnosis and treatment of ACTH-independent macronodular adrenal hyperplasia. Canadian Urological Association Journal, 7(9-10), e594–7. https://doi.org/10.5489/cuaj.420