Ectopic Cushing’s syndrome due to retroperitoneal ACTH-producing paragangliomas

Authors

  • Fan Chen Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Xiangyu Wang Department of Urology, Qilu Hospital, Shandong University, 107# Wenhua Xi Road, Jinan, Shandong
  • Yang Wang Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan
  • Hui Meng Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Yaofeng Zhu Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Wei Gao Department of Pathology, Qilu Hospital, Shandong University, Jinan, Shandong; Department of Pathology, Jinan Central Hospital, Shandong University, Jinan, Shandong
  • Xuewen Jiang Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Shouzhen Chen Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Zhaocun Zhang Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Zhichuan Zou Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Tianyi He Department of Endocrinology, Qilu Hospital, Shandong University, Jinan
  • Yue Yang Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Kejia Zhu Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Yong Wang Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Yaxiao Liu Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Jianfeng Cui Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Benkang Shi Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong
  • Gang Yin Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong

DOI:

https://doi.org/10.5489/cuaj.3153

Abstract

Extra-adrenal pheochromocytomas, or paragangliomas, are rare tumours that derive from extra-adrenal chromaffin cells. Cushing’s syndrome (CS) caused by paragangliomas is extremely rare. We report a 53-year-old man with hypertension, diabetes, and symptoms of hypokalemia. Computer tomography (CT) revealed two retroperitoneal masses and bilateral adrenal hyperplasia. Together with the laboratory examinations, ectopic CS caused by multiple paragangliomas was highly suspected. The patient underwent resections of retroperitoneal tumours, left kidney, and left adrenal; postoperative histopathology confirmed two paragangliomas that were both positively stained for adrenocorticotropic hormone (ACTH). He got clinical and biochemical recoveries without any recurrent evidence at the nine-month followup.

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Published

2016-09-13

How to Cite

Chen, F., Wang, X., Wang, Y., Meng, H., Zhu, Y., Gao, W., Jiang, X., Chen, S., Zhang, Z., Zou, Z., He, T., Yang, Y., Zhu, K., Wang, Y., Liu, Y., Cui, J., Shi, B., & Yin, G. (2016). Ectopic Cushing’s syndrome due to retroperitoneal ACTH-producing paragangliomas. Canadian Urological Association Journal, 10(9-10), E320–3. https://doi.org/10.5489/cuaj.3153

Issue

Vol. 10 No. 9-10 (2016): CUAJ September

Section

Case Report

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