Bladder tumour antigen (BTA stat) test compared to the urine cytology in the diagnosis of bladder cancer: A meta-analysis

Authors

  • Aiye Guo Department of Clinical Laboratory, Henan Province People's Hospital
  • Xiuhua Wang The foreign affairs division of scientific research, Henan Province People's Hospital
  • Juan Shi Department of Clinical Laboratory, Henan Province People's Hospital
  • Changyi Sun Department of Clinical Laboratory, Henan Province People's Hospital
  • Zhen Wan Department of Clinical Laboratory, Henan Province People's Hospital

DOI:

https://doi.org/10.5489/cuaj.1668

Keywords:

Bladder tumor antigen, Urine cytology, Bladder cancer, Meta-analysis

Abstract

Introduction: We evaluate the diagnostic value of bladder tumour antigen (BTA stat) tests compared with urine cytology test in detecting bladder cancer.

Methods: We searched public databases including PubMed, MEDLINE Springer, Elsevier Science Direct, Cochrane Library and Google Scholar before December 2012. To collect relevant data of BTA stat tests and urine cytology tests in patients with bladder cancer, we studied meta-analyses of sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratios (DOR) of BTA stat tests and cytology tests from published studies. We applied the software of Rev. Man 5.1 and Stata 11.0 to the meta-analysis.

Results: A total of 13 separate studies consisting of 3462 patients with bladder cancer were considered in the meta-analysis. We found that the BTA stat test had a higher sensitivity than the urine cytology test (0.67, 95% confidence interval [CI] 0.64 to 0.69 vs. 0.43, 95% CI 0.40 to 0.46), but the specificity, positive LR, negative LR, DOR, the area under the curve (AUC) and Q index of the BTA stat test were lower compared with the urine cytology test. The results of the Egger’s linear regression test showed no publication bias (p > 0.05).

Conclusions: Specificity, positive LR, negative LR, DOR, the AUC and the Q index of the urine cytology test may be superior to the BTA stat test, but the BTA stat test has greater sensitivity than the urine cytology test.

 

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Published

2014-05-21

How to Cite

Guo, A., Wang, X., Shi, J., Sun, C., & Wan, Z. (2014). Bladder tumour antigen (BTA stat) test compared to the urine cytology in the diagnosis of bladder cancer: A meta-analysis. Canadian Urological Association Journal, 8(5-6), e347–52. https://doi.org/10.5489/cuaj.1668

Issue

Section

Original Research