Complications de l’hormonothérapie anti-androgénique du cancer de la prostate

Authors

  • Imad Ziouziou Service d'urologie B, CHU ibn sina, rabat
  • Tariq Karmouni
  • Khalid El khader
  • Abdellatif Koutani
  • Aahmed Iben attya andaloussi

DOI:

https://doi.org/10.5489/cuaj.1608

Keywords:

androgen deprivation therapy, castration, prostate cancer

Abstract

Les effets indésirables de l’hormonothérapie anti-androgénique (HAA) dans le traitement du cancer de la prostate sont attribuables à la carence d’androgènes. L’HAA entraîne le syndrome de castration, qui se caractérise par une diminution de la libido, la dysfonction érectile, l’asthénie, des bouffées de chaleur, la diminution des capacités intellectuelles et la dépression. Il en résulte également une augmentation de la graisse abdominale, ce qui favorise l’insulinorésistance et le diabète. La perte de la densité minérale osseuse secondaire à l’HAA entraîne un risque fracturaire accru. Il existe de plus un risque cardiovasculaire important dû aux facteurs métaboliques. L’effet thérapeutique de l’HAA doit donc être soupesé en regard de la toxicité liée à l’hypogonadisme.

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Published

2014-03-11

How to Cite

Ziouziou, I., Karmouni, T., El khader, K., Koutani, A., & Iben attya andaloussi, A. (2014). Complications de l’hormonothérapie anti-androgénique du cancer de la prostate. Canadian Urological Association Journal, 8(3-4), e159–62. https://doi.org/10.5489/cuaj.1608

Issue

Vol. 8 No. 3-4 (2014): CUAJ March

Section

Review

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