Acute reversible kidney injury secondary to bilateral ureteric obstruction

Auteurs-es

  • Michael Organ Department of Urology, Dalhousie University, Halifax, NS
  • Richard W. Norman Department of Urology, Dalhousie University, Halifax, NS

DOI :

https://doi.org/10.5489/cuaj.726

Résumé

Background: Acute reversible kidney injury (ARKI) secondary to
bilateral ureteric obstruction (BUO) is a common urological problem.
Our goals were to describe the etiology, management and
outcomes of such patients identified between 2006 and 2009 and
to compare them with a similar historical study published in 1982.

Methods: Chart review was performed on 49 patients with AKRI
secondary to BUO. ARKI was defined as ≥33% decrease in serum
creatinine after intervention. Those with malignant and benign
causes of obstruction were identified and management and outcome
data were collected.

Results: Of these 49 patients, 83% had BUO secondary to malignancy,
28% of these presenting for the first time. Prevalence of
bladder cancer was increased (p = 0.04) and cervix trended lower
(p = 0.07) compared with the earlier study; prostate cancer was
unchanged (p = 0.51). The average survival was 239 days; 90%
of patients died within a year after presenting with BUO from a
malignant etiology. Compared with the 1982 group, there were
trends towards a decrease in the frequency of retroperitoneal fibrosis
(p = 0.08) and an increase in bilateral ureteric calculi (p = 0.16)
in the benign group.

Conclusions: Patients with ARKI secondary to BUO most likely
have an underlying malignancy, with almost a third of them being
diagnosed for the first time. Prevalence of bladder cancer increased
while cervical cancer trended lower. The cause for the former is
unclear; the latter may be due to aggressive screening. Prostate cancer
remained unchanged despite the widespread implementation of
prostate-specific antigen testing. Patients with an underlying malignancy
do poorly and those with a newly diagnosed malignancy
do worst. Those with ARKI secondary to benign causes did well.

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Bibliographies de l'auteur-e

Michael Organ, Department of Urology, Dalhousie University, Halifax, NS

Richard W. Norman, Department of Urology, Dalhousie University, Halifax, NS

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Comment citer

Organ, M., & Norman, R. W. (2013). Acute reversible kidney injury secondary to bilateral ureteric obstruction. Canadian Urological Association Journal, 5(6), 392–6. https://doi.org/10.5489/cuaj.726

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Rubrique

Original Research