Successful neoadjuvant chemotherapy for primary invasive small-cell carcinoma of the ureter

Authors

  • Kimito Osaka Yokohama City University
  • Kazuki Kobayashi Yokosuka Kyosai Hospital
  • Naoki Sakai Yokosuka Kyosai Hospital
  • Sumio Noguchi Yokosuka Kyosai Hospital

DOI:

https://doi.org/10.5489/cuaj.2372

Keywords:

small-cell carcinoma, ureter, neoadjuvant chemotherapy

Abstract

We report a case of invasive small-cell carcinoma (SCC) of the ureter successfully treated by neoadjuvant chemotherapy and laparoscopic nephroureterectomy. SCC of the ureter is an extremely rare condition characterized by aggressive behaviour. A 70-yearold male presented with left flank pain; he was diagnosed with SCC of the ureter, cT3N0M0, by ureteroscopic biopsy. The patient received 3 cycles of neoadjuvant chemotherapy with cisplatin and irinotecan (IP) and underwent laparoscopic nephroureterectomy. The pathological diagnosis was urothelial carcinoma, high grade, without a small-cell component. The pathological stage was downstaged to pT2N0M0. Adjuvant chemotherapy was not performed. The patient has been free of local recurrence or distant metastasis for 38 months postoperatively. This is the first reported case of primary invasive SCC of the upper urinary tract treated by neoadjuvant chemotherapy followed by nephroureterectomy.

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Author Biographies

Kimito Osaka, Yokohama City University

Department of Urology Assistant Professor

Kazuki Kobayashi, Yokosuka Kyosai Hospital

Department of Urology

Naoki Sakai, Yokosuka Kyosai Hospital

Department of Urology

Sumio Noguchi, Yokosuka Kyosai Hospital

Department of Urology

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Published

2015-06-18

How to Cite

Osaka, K., Kobayashi, K., Sakai, N., & Noguchi, S. (2015). Successful neoadjuvant chemotherapy for primary invasive small-cell carcinoma of the ureter. Canadian Urological Association Journal, 9(5-6), E393–6. https://doi.org/10.5489/cuaj.2372

Issue

Vol. 9 No. 5-6 (2015): CUAJ June

Section

Case Report

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