Sequential treatments in hereditary leiomyomatosis and renal cell carcinoma (HLRCC): Case report and review of the literature

Auteurs-es

  • Guillermo de Velasco University Hospital 12 de Octubre. Madrid. Spain
  • Cesar Munoz University Hospital 12 de Octubre. Madrid. Spain
  • Juan M. Sepulveda University Hospital 12 de Octubre. Madrid. Spain
  • Daniel Castellano University Hospital 12 de Octubre. Madrid. Spain

DOI :

https://doi.org/10.5489/cuaj.2264

Mots-clés :

Papillary renal carcinoma, leiomiomatosis, Gemcitabine, Bevacizumab.

Résumé

The overall survival for patients with advanced papillary renal carcinoma (RCC) is still limited. Although multikinase inhibitors have recently been developed for clear cell carcinoma, response rates in other histology non-clear cell RCC are poor and patients often face dose-limiting toxicities which lead to a reduction in prognosis and treatment success. We present a patient with hereditary leiomyomatosis and RCC (HLRCC), showing a sustained response for more than 12 months to gemcitabine-bevacizumab therapy after failure tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) therapies.

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Bibliographies de l'auteur-e

Guillermo de Velasco, University Hospital 12 de Octubre. Madrid. Spain

Deparment Uro-Oncology.

Clinical Research Fellow

Cesar Munoz, University Hospital 12 de Octubre. Madrid. Spain

Deparment of Oncology. Specialty training

Juan M. Sepulveda, University Hospital 12 de Octubre. Madrid. Spain

Deparment Uro-Oncology

Consutant of Medical Oncology

Daniel Castellano, University Hospital 12 de Octubre. Madrid. Spain

Deparment Uro-Oncology

Consultant of Medical Oncology

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Publié-e

2015-04-13

Comment citer

de Velasco, G., Munoz, C., Sepulveda, J. M., & Castellano, D. (2015). Sequential treatments in hereditary leiomyomatosis and renal cell carcinoma (HLRCC): Case report and review of the literature. Canadian Urological Association Journal, 9(3-4), E243–6. https://doi.org/10.5489/cuaj.2264

Numéro

Rubrique

Case Report