Ovarian metastasis of clear cell renal cell carcinoma: A case report

Authors

  • Lenka Bauerová Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
  • Pavel Dundr Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
  • Daniela Fischerová Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
  • Michal Pešl Department of Urology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
  • Michal Zikán Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
  • Andrea Burgetová Department of Radiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague

DOI:

https://doi.org/10.5489/cuaj.1456

Keywords:

Ovarian clear cell carcinoma, Metastasis of clear cell renal cell carcinoma, Ovarian metastases

Abstract

We report on a 61-year-old woman with a history of right-sided nephrectomy for clear cell renal cell carcinoma (RCC) occurring 21 years ago; she currently presented with a bilateral ovarian tumour. Histologically, the tumour of both ovaries was clear cell carcinoma. Immunohistochemically, the tumour cells were positive for vimentin, RCC marker, epithelial membrane antigen, cytokeratin AE1/3 and CD10. Cytokeratin 7, CA125, HMWCK, estrogen and progesterone receptors were all negative. Based on the morphologyand immunophenotype of the tumour, we established a diagnosis of late metastasis of RCC in the ovaries. A postoperative abdominal computed tomography scan, however, revealed a tumour mass solely in the left kidney, which had not been visible in the preoperative ultrasound. The patient underwent nephron-sparing surgery and a biopsy showed the tumour to be clear cell RCC. Metastasis of RCC to the ovaries is rare, and to the best of our knowledge, only 24 cases have been reported to date. However, due to the different treatments and prognosis, the distinction between a primary ovarian tumour and metastasis of RCC is important.

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Published

2014-03-11

How to Cite

Bauerová, L., Dundr, P., Fischerová, D., Pešl, M., Zikán, M., & Burgetová, A. (2014). Ovarian metastasis of clear cell renal cell carcinoma: A case report. Canadian Urological Association Journal, 8(3-4), e188–92. https://doi.org/10.5489/cuaj.1456

Issue

Vol. 8 No. 3-4 (2014): CUAJ March

Section

Case Report

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