3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in histopathologically benign biopsy cores

Authors

  • Brian Reguly Genesis Genomics Inc., Thunder Bay, ON
  • John P. Jakupciak National Institute of Standards and Technology, Biochemical Science Division, Gaithersburg, MD
  • Ryan L. Parr Genesis Genomics Inc., Thunder Bay, ON

DOI:

https://doi.org/10.5489/cuaj.932

Abstract

Recently, we described a 3.4-kb mitochondrial genome deletion
having significance for identifying malignant and benign prostate
tissues (p < 0.001). This biomarker was also present in normal
appearing tissue, in close proximity to a tumour indicating a “field
effect.” In the present study, we report 4 cases (3 malignant, 1
benign) which suggest that this field effect may occur before
tumourigenesis; this effect may also identify the presence of a
small tumour focus/foci, which are difficult to detect with single
or multiple biopsy procedures.

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Author Biographies

Brian Reguly, Genesis Genomics Inc., Thunder Bay, ON

John P. Jakupciak, National Institute of Standards and Technology, Biochemical Science Division, Gaithersburg, MD

Ryan L. Parr, Genesis Genomics Inc., Thunder Bay, ON

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How to Cite

Reguly, B., Jakupciak, J. P., & Parr, R. L. (2013). 3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in histopathologically benign biopsy cores. Canadian Urological Association Journal, 4(5), E118-E122. https://doi.org/10.5489/cuaj.932

Issue

Vol. 4 No. 5 (2010): CUAJ October

Section

Case Report

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