Correlates and predictors of sarcopenia among men with metastatic castrate-resistant prostate cancer

Authors

  • Efthymios Papadopoulos School of Kinesiology, Louisiana State University, Baton Rouge, Louisiana
  • Andy Kin On Wong University of Toronto
  • Sharon Hiu Ching Law University of Toronto
  • Lindsey Ze Jing Zhang University Health Network, Toronto
  • Henriette Breunis University Health Network, Toronto
  • Urban Emmenegger Sunnybrook Health Sciences Centre, Toronto
  • Shabbir M.H. Alibhai Princess Margaret Cancer Centre, Toronto

DOI:

https://doi.org/10.5489/cuaj.8803

Keywords:

sarcopenia, muscle mass, muscle strength, physical performance, prostate cancer, metastasis, hemoglobin

Abstract

INTRODUCTION: Sarcopenia is a predictor of clinical outcomes in men with metastatic castrate-resistant prostate cancer (mCRPC); however, correlates and predictors of sarcopenia are poorly understood in this population. The aim of this study was to examine correlates and predictors of sarcopenia in men with mCRPC prior to treatment.

METHODS: A secondary analysis of an observational study was performed. Participants were receiving care for mCRPC at the Princess Margaret Cancer Centre. Sarcopenia was assessed prior to treatment and was defined as the combination of low grip strength (<35.5 kg), low gait speed (<0.8 m/s), and computed tomography-derived low muscle mass or density. Participants’ sociodemographic and clinical characteristics, comorbidity information, and clinically relevant blood markers were collected prior to treatment and were used to identify correlates and predictors of sarcopenia through Spearman correlations and multivariable logistic regression, respectively.

RESULTS: In total, 110 men had complete data on sarcopenia measures and were included in the analysis. Sarcopenia was identified in 30 (27.3%) participants. Pre-treatment sarcopenia was moderately correlated with dependence in one or more instrumental activities of daily living (IADLs) (r=0.412), Vulnerable Elders Survey-13 (r=0.404), and a lower hemoglobin (r=0.407 per 10 g/L decrease). In adjusted logistic regression, dependence in one or more IADLs (odds ratio [OR] 4.37, 95% confidence interval [CI] 1.37–13.86, p=0.012), and a 10 g/L decrease in hemoglobin (OR 1.70, 95% CI 1.13–2.57, p=0.012) were significantly associated with sarcopenia.

CONCLUSIONS: In settings where assessment of sarcopenia is not feasible, evaluation of IADLs and hemoglobin may be used to identify high-risk patients that can benefit from supportive care strategies aiming to improve muscle mass and function.

Downloads

Download data is not yet available.

Downloads

Published

2024-07-15

How to Cite

Papadopoulos, E., Wong, A. K. O. ., Law, S. H. C. ., Zhang, L. Z. J., Breunis, H., Emmenegger, U. ., & Alibhai, S. M. (2024). Correlates and predictors of sarcopenia among men with metastatic castrate-resistant prostate cancer. Canadian Urological Association Journal, 18(12), 405–12. https://doi.org/10.5489/cuaj.8803

Issue

Vol. 18 No. 12 (2024): CUAJ December

Section

Original Research

License

You, the Author(s), assign your copyright in and to the Article to the Canadian Urological Association. This means that you may not, without the prior written permission of the CUA:

  • Post the Article on any Web site
  • Translate or authorize a translation of the Article
  • Copy or otherwise reproduce the Article, in any format, beyond what is permitted under Canadian copyright law, or authorize others to do so
  • Copy or otherwise reproduce portions of the Article, including tables and figures, beyond what is permitted under Canadian copyright law, or authorize others to do so.

The CUA encourages use for non-commercial educational purposes and will not unreasonably deny any such permission request.

You retain your moral rights in and to the Article. This means that the CUA may not assert its copyright in such a way that would negatively reflect on your reputation or your right to be associated with the Article.

The CUA also requires you to warrant the following:

  • That you are the Author(s) and sole owner(s), that the Article is original and unpublished and that you have not previously assigned copyright or granted a licence to any other third party;
  • That all individuals who have made a substantive contribution to the article are acknowledged;
  • That the Article does not infringe any proprietary right of any third party and that you have received the permissions necessary to include the work of others in the Article; and
  • That the Article does not libel or violate the privacy rights of any third party.