Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Authors

  • Patrick Albers Urology Resident - University of Alberta
  • Jacob Bennett
  • Moira Evans
  • Ella St. Martin
  • Betty Wang
  • Stacey Broomfield
  • Anaïs Medina Martín
  • Wendy Tu
  • Christopher Fung
  • Adam Kinnaird

DOI:

https://doi.org/10.5489/cuaj.8626

Keywords:

Prostate Cancer, Microultrasound, Prostate Biopsy

Abstract

Introduction: Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging technology that could visualize csPCa that is missed by MRI.

Methods: This retrospective review included 1011 consecutive patients biopsied between September 2021 and July 2023 in Alberta, Canada. Among them were 103 biopsy-naive patients with negative MRI (Prostate Imaging Reporting & Data System [PI-RADS] ≤2) undergoing microUS-informed prostate biopsy (n=56) scored using Prostate Risk Identification Using Micro-ultrasound (PRI-MUS) or standard transrectal ultrasound prostate biopsy (n=47). The primary outcome was detection rate of csPCa stratified by biopsy technique and PRI-MUS score.

Results: MicroUS biopsy identified csPCa in 14/56 (25%) compared to standard biopsy in 8/47 (17%) (p=0.33). Patients with lesions PRI-MUS ≥3 had csPCa detected at a higher rate compared to patients with PRI-MUS ≤2 (42% vs. 16%, p=0.03). The csPCa detection rate was significantly different comparing patients with PSA density <0.15 and PRI-MUS ≤2 compared to patients with PSA density ≥0.15 and PRI-MUS ≥3 (14% vs. 60%, p=0.02).

Conclusions: MicroUS may aid in the detection of csPCa for patients with negative MRI.

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Published

2024-04-02

How to Cite

Albers, P., Bennett, J., Evans, M., St. Martin, E., Wang, B., Broomfield, S., Medina Martín , A., Tu, W., Fung, C., & Kinnaird, A. (2024). Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI. Canadian Urological Association Journal, 18(6). https://doi.org/10.5489/cuaj.8626

Issue

Vol. 18 No. 6 (2024): CUAJ June

Section

Original Research

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