Efficacy and safety of TURP, HoLEP, and PVP in the management of OAB symptoms complicating BPH in patients with moderately enlarged prostates

A comparative study

Authors

  • Mostafa M. Mostafa University of Cincinnati College of Medicine
  • Ashraf Khallaf University of Cincinnati College of Medicine
  • Mahmoud Khalil Asiut University Hospitals and School of Medicine
  • Mohammed A. Elgammal Asiut University Hospitals and School of Medicine
  • Ayman Mahdy University of Cincinnati College of Medicine

DOI:

https://doi.org/10.5489/cuaj.7905

Keywords:

Transurethral Resection of the Prostate (TURP), Holmium Laser Enucleation of the Prostate (HoLEP), Photoselective Vaporization of the Prostate (PVP), Benign Prostatic Hyperplasia (BPH), overactive bladder (OAB) symptoms

Abstract

Introduction: We aimed to compare the effectiveness and safety of transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HoLEP), and photoselective vaporization of the prostate (PVP) in management of storage and overactive bladder (OAB) symptoms complicating benign prostatic hyperplasia (BPH) in patients with moderately enlarged prostates.

Methods: The charts of patients with moderately enlarged prostates and BPH complicated by storage and OAB symptoms who were treated by TURP, HoLEP, and PVP at University of Cincinnati hospitals between March 2012 and December 2020 were retrospectively reviewed and analyzed for changes in storage and OAB symptomatology, International Prostate Symptom Score (IPSS), peak flow rates (Qmax), presence of detrusor overactivity (DO), and postvoid residual (PVR) from baseline to up to six months postoperatively.

Results: A total of 204 patients with moderately enlarged prostates and BPH complicated by storage and OAB symptoms were divided into three groups: group 1 (patients who underwent TURP, 89 patients), group 2 (those who underwent HoLEP, 64 patients), and group 3 (those who underwent PVP, 51 patients). TURP, HoLEP, and PVP were associated with significant improvement in urodynamics study (UDS) parameters, patient storage and OAB symptomatology, and IPSS from preoperatively to both three and six months postoperatively in BPH patients with moderately enlarged prostates, with relatively low procedure complication rate and postoperative need for either anticholinergic or procedure.

Conclusions: TURP, HoLEP, and PVP are effective and reliable surgical procedures that can be relied upon for BPH patients with moderately enlarged prostates and storage or OAB symptoms, with comparable efficacy and relatively low procedure complication rate and postoperative need for anticholinergic or additional procedure.

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Author Biographies

Mostafa M. Mostafa, University of Cincinnati College of Medicine

Research Fellow of Urology,

Division of Urology, Department of Surgery,
University of Cincinnati College of Medicine,
231 Albert Sabin Way,
Cincinnati, OH 45267

Assistant Lecturer of Urology,

Asiut University Hospitals,

Asiut, Egypt,

E-mail: mostafmm@ucmail.uc.edu

Phone number: +1 (513) 918-8299

ORCID ID: 0000-0002-8750-6236

Ashraf Khallaf, University of Cincinnati College of Medicine

Visiting Scholar of Urology,

Department of Surgery,

University of Cincinnati College of Medicine,

231 Albert Sabin Way,
Cincinnati, OH 45267

E-mail: ashraf.m.khallaf2@gmail.com

Mahmoud Khalil, Asiut University Hospitals and School of Medicine

Lecturer of Urology,

Asiut University Hospitals and School of Medicine,

Asiut, Egypt,

E-mail: mahmoudkhalil@aun.edu.eg

Phone number: +2 01003853441

Mohammed A. Elgammal, Asiut University Hospitals and School of Medicine

Professor of Urology,

Asiut University Hospitals and School of Medicine,

Asiut, Egypt,

E-mail: mohammedelgammal@aun.edu.eg

Phone number: +2 01005212163

Ayman Mahdy, University of Cincinnati College of Medicine

Interim Chief of Urology,

Professor of Urology,

Bruce and Barbara Bracken Endowed Chair in Surgical Urology,

Director of Voiding Dysfunction and Female Urology,

Medical Director of Urology, the West Chester Hospital,

Department of Surgery,
University of Cincinnati College of Medicine,
231 Albert Sabin Way, ML 0589,
Cincinnati, OH 45267

E-mail: mahdyan@uc.edu

Phone number: +1 (513) 500-2316
Fax: +1 (513) 558-3575

 

Published

2022-08-30

How to Cite

Mostafa, M. M., Khallaf, A., Khalil, M., Elgammal, M. A., & Mahdy, A. (2022). Efficacy and safety of TURP, HoLEP, and PVP in the management of OAB symptoms complicating BPH in patients with moderately enlarged prostates: A comparative study. Canadian Urological Association Journal, 17(1), E1–7. https://doi.org/10.5489/cuaj.7905

Issue

Section

Original Research