Drugs and future candidates
DOI:
https://doi.org/10.5489/cuaj.710Abstract
Antimuscarinic drugs are still first-line treatment for the symptomsof overactive bladder (OAB) and are associated with good initial
response rates. Adverse effects and decreasing efficacy over
the longer term do, however, limit their overall effectiveness. As
such, alternatives to antimuscarinics are needed. The recognition
of the functional contribution of the urothelium, the spontaneous
myocyte activity during bladder filling, and the diversity of nerve
transmitters involved in the symptoms of the OAB has sparked
interest in pharmacologic manipulation of both peripheral and
central pathophysiology. Some of the treatments currently under
investigation are discussed in this review.
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How to Cite
Andersson, K.-E. (2013). Drugs and future candidates. Canadian Urological Association Journal, 5(5-S2), S131-S133. https://doi.org/10.5489/cuaj.710
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