An evaluation of the role of tumor load in cytoreductive nephrectomy

  • Andrew W. Silagy
  • Cihan Duzgol
  • Julian Marcon
  • Renzo G. DiNatale
  • Roy Mano
  • Kyle A. Blum
  • Ed Reznik
  • Martin H. Voss
  • Robert J. Motzer
  • Jonathan A. Coleman
  • Paul Russo
  • Oguz Akin
  • A. Ari Hakimi Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, NY
Keywords: Volume, Sphericity, Metastasis, Cytoreductive nephrectomy, Renal cell carcinoma, Survival

Abstract

Introduction: New radiological tools can accurately provide preoperative three-dimensional spatial assessment of metastatic renal cell carcinoma (RCC). We aimed to determine whether the distribution, volume, shape, and fraction of RCC resected in a cytoreductive nephrectomy associates with survival.

Methods: We retrospectively reviewed 560 patients undergoing cytoreductive nephrectomy, performing a comprehensive volumetric analysis in eligible patients of all detectable primary and metastatic RCC prior to surgery. We used Cox regression analysis to determine the association between the volume, shape, fraction resected, and distribution of RCC and overall survival (OS).

Results: There were 62 patients eligible for volumetric analysis, with similar baseline characteristics to the entire cohort, and median survivor followup was 34 months. Larger primary tumors were less spherical, but not associated with different metastatic patterns. Increased primary tumor volume and tumor size, but not the fraction of tumor resected, were associated with inferior survival. The rank of tumors based on unidimensional size did not completely correspond to the rank by primary tumor volume, however, both measurements yielded similar concordance for predicted OS. Larger tumor volume was not associated with a longer postoperative time off treatment.

Conclusions: Primary tumor volume was significant for predicting OS, while the fraction of disease resected did not appear to impact patient outcomes. Although rich in detail, our study is potentially limited by selection bias. Future temporal studies may help elucidate whether the primary tumor shape is associated with tumor growth kinetics.

Published
2020-06-16
How to Cite
Silagy, A. W., Duzgol, C., Marcon, J., DiNatale, R. G., Mano, R., Blum, K. A., Reznik, E., Voss, M. H., Motzer, R. J., Coleman, J. A., Russo, P., Akin, O., & Hakimi, A. A. (2020). An evaluation of the role of tumor load in cytoreductive nephrectomy. Canadian Urological Association Journal, 14(12), E625-30. https://doi.org/10.5489/cuaj.6350
Section
Original Research