Evaluating factors that dictate struvite stone composition: A multi-institutional clinical experience from the EDGE Research Consortium

  • Ryan K. Flannigan The Stone Center at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia, Vancouver BC
  • Andrew Battison The Stone Center at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia, Vancouver BC
  • Shubha De Stevan Streem Center of Endourology & Stone Disease, The Cleveland Clinic, Cleveland, Ohio, USA
  • Mitchell R. Humphreys Department of Urology, Mayo Clinic, Phoenix, Arizona, Mayo Clinic, Phoenix Arizona
  • Markus Bader UroClinic München Giesig, Munich, Germany
  • Ekaterina Lellig Klinikum Grosshadern der Universität München, Munich, Germany
  • Manoj Monga Stevan Streem Center of Endourology & Stone Disease, The Cleveland Clinic, Cleveland, Ohio, USA
  • Ben H. Chew The Stone Center at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia, Vancouver BC
  • Dirk Lange The Stone Center at Vancouver General Hospital, Department of Urologic Sciences, University of British Columbia, Vancouver BC

Abstract

Introduction: Struvite stones account for 15% of urinary calculi and are typically associated with urease-producing urinary tract infections and carry significant morbidity. This study aims to characterize struvite stones based on purity of stone composition, bacterial speciation, risk factors, and clinical features.

Methods: Retrospective data was collected from patients diagnosed with infection stones between 2008 and 2012. Stone analysis, perioperative urine cultures, bacterial speciation, and clinical data were collected and analyzed. The purity of struvite stones was determined. Statistical comparisons were made among homogeneous and heterogeneous struvite stones.

Results: From the four participating centres, 121 struvite stones were identified. Only 13.2% (16/121) were homogenous struvite. Other components included calcium phosphate (42.1%), calcium oxalate (33.9%), calcium carbonate (27.3%), and uric acid (5.8%). Partial or full staghorn calculi occurred in 23.7% of cases. Ureaseproducing bacteria were only present in 30% of cases. Proteus, E. coli, and Enterococcus were the most common bacterial isolates from perioperative urine, and percutaneous nephrolithotomy was the most common modality of treatment. Only 40% of patients had a urinalysis that was nitrite-positive, indicating that urinalysis alone is not reliable for diagnosing infection stones. The study’s limitation is its retrospective nature; as such, the optimal timing of cultures with respect to stone analysis or treatment was not always possible, urine cultures were often not congruent with stone cultures in the same patient, and our findings of E. coli commonly cultured does not suggest causation.

Conclusions: Struvite stones are most often heterogeneous in composition. Proteus remains a common bacterial isolate; however, E. coli and Enterococcus were also frequently identified. This new data provides evidence that patients with struvite stones can have urinary tract pathogens other than urease-producing bacteria, thus challenging previous conventional dogma.

Published
2017-12-16
How to Cite
Flannigan, R. K., Battison, A., De, S., Humphreys, M. R., Bader, M., Lellig, E., Monga, M., Chew, B. H., & Lange, D. (2017). Evaluating factors that dictate struvite stone composition: A multi-institutional clinical experience from the EDGE Research Consortium. Canadian Urological Association Journal, 12(4), 131-6. https://doi.org/10.5489/cuaj.4804
Section
Original Research