Conservative treatment of upper urinary tract carcinoma: Long-term results

  • Andrea Orosa Andrada Ramon y Cajal Hospital
  • Inés Laso García Ramón y Cajal Hospital
  • Fernando Arias Fúnez Ramon y Cajal Hospital
  • Francisco Donis Canet Ramón y Cajal Hospital
  • Gemma Duque Ruiz Ramón y Cajal Hospital
  • Victoria Gómez Dos Santos Ramón y Cajal Hospital
  • Francisco Javier Burgos Revilla Ramón y Cajal Hospital

Abstract

Introduction: We sought to assess the long-term results of conservative treatment for upper urinary tract carcinoma (UUTC) with regard to tumour recurrence and preservation of renal unit.

Methods: From October 1987 to January 2014, 65 patients (median age 68 years) were diagnosed with UUTC and underwent endoscopic and open surgical techniques. Thirteen patients had bilateral disease and one had a single kidney. The primary approach was endoscopic in 37 reno-ureteral units (20 percutaneous resections, 17 ureteroscopies ). Open surgery was performed in 19 cases. A total of 20 patients received mitomycin C.

Results: Superficial stage pTa or T1 was noted in 37 patients, infiltrating stage pT2 and pT3 in seven and inverted papilloma in one. The stage of the tumour was impossible to classify in 20. With a median followup of 75.12 months (interquartile range [IQR] 144.71–17.41), the kidney preservation, recurrence, specific survival, and global survival rates were 78.5% (51/65), 40.0% (26/65), 92.3% (60/65), and 69.2% (45/65), respectively. From the patients who had recurrence, 15 were salvaged with radical nephroureterectomy (RNU). The bladder tumour recurrence rate after the surgery was 30.76% (20/65). At the end of the followup, five patients had died of UUTC progression and 16 from other causes. Postoperative complications included one case of fistula, one case of stricture, and one case of nephrectomy due to bleeding.

Conclusions: In selected cases, conservative management is a safe and feasible alternative to RNU, with the advantage of renal unit preservation.

Author Biographies

Andrea Orosa Andrada, Ramon y Cajal Hospital

Urology Department

Staff

Inés Laso García, Ramón y Cajal Hospital

Urology Department

Staff

Fernando Arias Fúnez, Ramon y Cajal Hospital

Urology Department

Staff

Francisco Donis Canet, Ramón y Cajal Hospital

Urology Department

Resident

Gemma Duque Ruiz, Ramón y Cajal Hospital

Urology Department

Staff

Victoria Gómez Dos Santos, Ramón y Cajal Hospital

Urology Department

Satff

Francisco Javier Burgos Revilla, Ramón y Cajal Hospital

Urology Department

Chief

Published
2017-07-11
How to Cite
Orosa Andrada, A., Laso García, I., Arias Fúnez, F., Donis Canet, F., Duque Ruiz, G., Gómez Dos Santos, V., & Burgos Revilla, F. J. (2017). Conservative treatment of upper urinary tract carcinoma: Long-term results. Canadian Urological Association Journal, 11(7), E291-6. https://doi.org/10.5489/cuaj.4173
Section
Original Research