Complete response to ethnylestradiol prolonged for almost two years in patients with castration-resistant prostate cancer

Authors

  • Hiroshi Hongo Keio University School of Medicine
  • Takeo Kosaka Keio University School of Medicine
  • Mototsugu Oya Keio University School of Medicine

DOI:

https://doi.org/10.5489/cuaj.2293

Keywords:

Androgen, Androgen receptor, Estrogen, Prostate cancer, Prostate specific antigen, Ethnylestradiol

Abstract

An 80-year-old man with an elevated prostate-specific antigen (PSA) level of 120 ng/mL) presented to the hospital in February 2011. A prostate needle biopsy was performed, and pathological examination revealed prostatic adenocarcinoma. The Gleason score was 4+5=9. Computed tomography revealed metastases of the pelvic lymph nodes. Combined androgen blockade was started. The PSA concentration decreased to 1.68 ng/mL, but started increasing again in August 2012 to 6.08 ng/mL. Although bicalutamide was discontinued due to antiandrogen withdrawal syndrome, the PSA concentration increased even more. The PSA concentration reached 21.62 ng/mL in September 2012, at which time ethnylestradiol was started. The PSA concentration decreased again and has remained below the limit of sensitivity for almost 2 years. To our knowledge, this is first case report describing a complete response to ethnylestradiol that lasted for almost 2 years in a patient with castration-resistant prostate cancer.

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Author Biographies

Hiroshi Hongo, Keio University School of Medicine

Department of Urology

Takeo Kosaka, Keio University School of Medicine

Department of Urology

Mototsugu Oya, Keio University School of Medicine

Department of Urology

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Published

2014-12-15

How to Cite

Hongo, H., Kosaka, T., & Oya, M. (2014). Complete response to ethnylestradiol prolonged for almost two years in patients with castration-resistant prostate cancer. Canadian Urological Association Journal, 8(11-12), e921–3. https://doi.org/10.5489/cuaj.2293