Urothelial carcinoma involving the distal penis

Authors

  • Shawn Dason Division of Urology, McMaster University, Hamilton, ON
  • Adeel Sheikh Division of Urology, McMaster University, Hamilton, ON
  • Jing Gennie Wang School of Medicine, Queen’s University, Kingston, ON
  • Syeda Tauqir Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON
  • Timothy O. Davies Division of Urology, McMaster University, Hamilton, ON
  • Bobby Shayegan Division of Urology, McMaster University, Hamilton, ON

DOI:

https://doi.org/10.5489/cuaj.167

Abstract

Urothelial carcinoma (UC) rarely metastasizes to the penis and

skin. We report the case of a 73-year-old man with UC metastases

to the corpus spongiosum and dermis of the distal penis. We

also review the clinicopathologic characteristics and management

options for UC metastasizing to the penis. The patient presented

with priapism and edema of the genital region. This follows a

5-year history of urothelial carcinoma in situ that progressed to

invasive cancer despite intravesical immunotherapy. Seventeen

months prior to presentation, the patient underwent a radical cystectomy

with adjuvant chemotherapy. The cystectomy specimen

demonstrated a pT4a N2 M0 G3 UC and margins were positive

for carcinoma in situ. Follow-up had been negative for recurrence

until his presentation with priapism. Incisional biopsy of the glans

revealed UC and radical penectomy was performed with negative

margins. The penile specimen demonstrated extensive involvement

of the corpus spongiosum by UC with lymphovascular invasion

and subepidermal involvement. Three months after penectomy,

the patient presented with inguinal nodal recurrence. Palliative

radiotherapy was administered and the patient passed away eight

months after surgery.

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Author Biographies

Shawn Dason, Division of Urology, McMaster University, Hamilton, ON

Division of Urology, McMaster University, Hamilton, ON

Adeel Sheikh, Division of Urology, McMaster University, Hamilton, ON

Division of Urology, McMaster University, Hamilton, ON

Jing Gennie Wang, School of Medicine, Queen’s University, Kingston, ON

School of Medicine, Queen’s University, Kingston, ON

Syeda Tauqir, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON

Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON

Timothy O. Davies, Division of Urology, McMaster University, Hamilton, ON

Division of Urology, McMaster University, Hamilton, ON

Bobby Shayegan, Division of Urology, McMaster University, Hamilton, ON

Division of Urology, McMaster University, Hamilton, ON

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Published

2012-12-18

How to Cite

Dason, S., Sheikh, A., Wang, J. G., Tauqir, S., Davies, T. O., & Shayegan, B. (2012). Urothelial carcinoma involving the distal penis. Canadian Urological Association Journal, 6(2). https://doi.org/10.5489/cuaj.167

Issue

Vol. 6 No. 2 (2012): CUAJ April

Section

Case Report

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