Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Authors

  • Shilo Lefresne Department of Radiation Oncology, BC Cancer Agency, Vancouver, BC
  • Alysa Fairchild Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB
  • Royce Johnson Department of Ophthalmology, University of Alberta, Edmonton, AB;
  • Jean Deschenes Pathology Department, Cross Cancer Institute, Edmonton, AB;
  • Laurie Russell University of Alberta Hospital, Edmonton, AB
  • John Pederson Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB

DOI:

https://doi.org/10.5489/cuaj.163

Abstract

Metastases to the eye or orbit as the initial presentation of genitourinary

malignancy are unusual and can be a diagnostic challenge.

We report an 81-year-old man who presented with pain and

proptosis in an eye that had been blind for 50 years. Radiologic

investigations identified a mass involving the left globe and orbit.

Histology of the enucleation specimen was consistent with a metastatic

poorly differentiated carcinoma suggestive of a prostate

primary. With the constellation of obstructive urinary symptoms,

an abnormal digital rectal examination, elevated prostate-specific

antigen and a positive bone scan, androgen deprivation therapy

was initiated for metastatic prostate cancer. After an initial response

to treatment, the patient’s disease progressed in a manner atypical

for prostate cancer. After describing our case, we review the

literature on ocular and orbital metastases and their relation to

genitourinary malignancies.

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Author Biographies

Shilo Lefresne, Department of Radiation Oncology, BC Cancer Agency, Vancouver, BC

Department of Radiation Oncology, BC Cancer Agency, Vancouver, BC

Alysa Fairchild, Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB

Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB

Royce Johnson, Department of Ophthalmology, University of Alberta, Edmonton, AB;

Department of Ophthalmology, University of Alberta,

Edmonton, AB;

Jean Deschenes, Pathology Department, Cross Cancer Institute, Edmonton, AB;

Pathology Department, Cross Cancer Institute, Edmonton, AB;

Laurie Russell, University of Alberta Hospital, Edmonton, AB

University of Alberta Hospital, Edmonton, AB

John Pederson, Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB

Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB

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Published

2012-12-17

How to Cite

Lefresne, S., Fairchild, A., Johnson, R., Deschenes, J., Russell, L., & Pederson, J. (2012). Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature. Canadian Urological Association Journal, 6(2). https://doi.org/10.5489/cuaj.163

Issue

Section

Case Report