Tissue engineering in urology
DOI:
https://doi.org/10.5489/cuaj.1155Abstract
Tissue engineering encompasses a multidisciplinary approach gearedtoward the development of biological substitutes designed to restore
and maintain normal function in diseased or injured tissues. This
article reviews the basic technology that is used to generate
implantable tissue-engineered grafts in vitro that will exhibit characteristics
in vivo consistent with the physiology and function of
the equivalent healthy tissue. We also examine the current trends
in tissue engineering designed to tailor scaffold construction, promote
angiogenesis and identify an optimal seeded cell source.
Finally, we describe several currently applied therapeutic modalities
that use a tissue-engineered construct. While notable progress
has clearly been demonstrated in this emerging field, these efforts
have not yet translated into widespread clinical applicability. With
continued development and innovation, there is optimism that the
tremendous potential of this field will be realized.
L’ingénierie tissulaire englobe une approche multidisciplinaire
axée sur le développement de substituts biologiques en vue de
rétablir et de maintenir la fonction normale de tissus lésés. L’article
qui suit passe en revue la technologie fondamentale utilisée pour
générer des greffons implantables produits par ingénierie in vitro
et possédant des caractéristiques in vivo correspondant aux tissus
sains équivalents sur les plans physiologique et fonctionnel.
Nous examinons également les tendances actuelles en ingénierie
tissulaire visant à adapter des échafaudages tissulaires, à promouvoir
l’angiogenèse et à dégager une source optimale de cellules
implantables. Enfin, nous décrivons plusieurs modalités thérapeutiques
actuellement mises en application utilisant un échafaudage
créé par ingénierie tissulaire. En dépit de progrès remarquables
dans ce domaine en effervescence, les efforts déployés ne se sont
pas encore traduits par une applicabilité clinique étendue. Des
développements et des percées continus permettent d’être optimiste
face au potentiel prodigieux de ce domaine.
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How to Cite
Matoka, D. J., & Cheng, E. Y. (2013). Tissue engineering in urology. Canadian Urological Association Journal, 3(5), 403–8. https://doi.org/10.5489/cuaj.1155
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