2-octyl cyanoacrylate with interrupted sutures vs continuous suturing in adult male circumcision

A randomized controlled pilot trial

Authors

  • Kayla Reynolds 1. Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, R3E 0T4
  • Avinash Sarcar Men’s Health Clinic Manitoba, Winnipeg, Manitoba, R3K 1M3
  • Amirreza Elahian Men’s Health Clinic Manitoba, Winnipeg, Manitoba, R3K 1M3 and Section of Urology, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, R3A 1R9
  • Robert Bard Men’s Health Clinic Manitoba, Winnipeg, Manitoba, R3K 1M3 and Section of Urology, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, R3A 1R9
  • Premal Patel Men’s Health Clinic Manitoba, Winnipeg, Manitoba, R3K 1M3 and 3. Section of Urology, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, R3A 1R9

DOI:

https://doi.org/10.5489/cuaj.9692

Keywords:

Adult circumcision, Wound closure, 2-octyl cyanoacrylate, Continuous sutures, Randomized controlled trial

Abstract

Introduction: This randomized controlled pilot study evaluated the use of 2-octyl cyanoacrylate (2-OCA) combined with four interrupted sutures vs. continuous suturing for wound closure in adult male circumcision. While continuous sutures are the current standard at the Men’s Health Clinic Manitoba, 2-OCA has demonstrated superior results in the context of cosmesis, postoperative pain, and operative time, as shown in pediatric populations. The primary objective was to assess cosmetic satisfaction. Secondary outcomes included operative time, postoperative pain, and complications.

Methods: A non-blinded, randomized controlled pilot study was conducted at a single ambulatory urology surgical center. Twenty patients undergoing circumcision were randomly assigned to receive either 2-OCA with four interrupted sutures or continuous suturing for wound closure. Data collected included demographic information, intraoperative time, postoperative pain, adverse events, and cosmetic satisfaction at six and 12 weeks.

Results: Cosmetic satisfaction at six and 12 weeks was similar between groups, both with a median of 5 (highly satisfied). Mean procedure time was shorter in the 2-OCA group compared to the continuous suture group (28.7 vs. 34.3 min, p=0.037). Postoperative pain was low in both groups and did not differ significantly; however, wound dehiscence occurred in 50% of 2-OCA cases, prompting early study termination.

Conclusions: Although 2-OCA with interrupted sutures may offer faster procedures and comparable cosmetic results, the observed complications do not support its routine use in adult circumcision. Larger, blinded trials are needed to further evaluate the safety of tissue adhesives and address current study limitations, including small sample size, non-blinded design, and reliance on patient-reported outcomes.

Downloads

Download data is not yet available.

Downloads

Published

2026-09-25

How to Cite

Reynolds, K., Sarcar, A., Elahian, A., Bard, R., & Patel, P. (2026). 2-octyl cyanoacrylate with interrupted sutures vs continuous suturing in adult male circumcision: A randomized controlled pilot trial. Canadian Urological Association Journal, 21(1). https://doi.org/10.5489/cuaj.9692

Issue

Vol. 21 No. 1 (2027): CUAJ January

Section

Original Research

License

You, the Author(s), assign your copyright in and to the Article to the Canadian Urological Association. This means that you may not, without the prior written permission of the CUA:

  • Post the Article on any Web site
  • Translate or authorize a translation of the Article
  • Copy or otherwise reproduce the Article, in any format, beyond what is permitted under Canadian copyright law, or authorize others to do so
  • Copy or otherwise reproduce portions of the Article, including tables and figures, beyond what is permitted under Canadian copyright law, or authorize others to do so.

The CUA encourages use for non-commercial educational purposes and will not unreasonably deny any such permission request.

You retain your moral rights in and to the Article. This means that the CUA may not assert its copyright in such a way that would negatively reflect on your reputation or your right to be associated with the Article.

The CUA also requires you to warrant the following:

  • That you are the Author(s) and sole owner(s), that the Article is original and unpublished and that you have not previously assigned copyright or granted a licence to any other third party;
  • That all individuals who have made a substantive contribution to the article are acknowledged;
  • That the Article does not infringe any proprietary right of any third party and that you have received the permissions necessary to include the work of others in the Article; and
  • That the Article does not libel or violate the privacy rights of any third party.