Histological changes in the human prostate after radiotherapy and salvage high intensity focused ultrasound

Authors

  • Venu Chalasani Departments of Surgery and Oncology, Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON
  • Carlos H. Martinez Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON
  • Andrew K. Williams Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON
  • Kevin Kwan Department of Pathology, Schulich School of Medicine & Dentistry, London, ON
  • Joseph L. Chin Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON

DOI:

https://doi.org/10.5489/cuaj.890

Abstract

The histological changes (both macroscopic and microscopic) in the
prostate following the combination of external beam radiotherapy
and salvage high intensity focused ultrasound (HIFU) have not
been previously described. This article describes the case of a
65-year-old male who presented with recurrent localized prostate
cancer after undergoing external beam radiotherapy for low-risk
prostate cancer. He was treated with salvage HIFU, and 4 weeks
later presented with symptoms and signs consistent with a prostatorectal
fistula. During a period of conservative management, his
serum prostate-specific antigen levels started rising after having
reached a nadir. A radical cystoprostatectomy and repair of fistula
were performed after conservative management failed. Histological
changes of dense fibrosis were noted in the region where the
prostate should have been located. A literature review of the
histological findings in the prostate after HIFU is discussed in this
article, as well as the available evidence for the management of
patients with local failure after the combination of external beam
radiotherapy and salvage HIFU.

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Author Biographies

Venu Chalasani, Departments of Surgery and Oncology, Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON

Carlos H. Martinez, Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON

Andrew K. Williams, Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON

Kevin Kwan, Department of Pathology, Schulich School of Medicine & Dentistry, London, ON

Joseph L. Chin, Divisions of Urology and Surgical Oncology, Schulich School of Medicine & Dentistry, London, ON

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How to Cite

Chalasani, V., Martinez, C. H., Williams, A. K., Kwan, K., & Chin, J. L. (2013). Histological changes in the human prostate after radiotherapy and salvage high intensity focused ultrasound. Canadian Urological Association Journal, 4(4), E100-E102. https://doi.org/10.5489/cuaj.890

Issue

Vol. 4 No. 4 (2010): CUAJ August

Section

Case Report

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