Bladder perforation after immediate postoperative intravesical instillation of mitomycin C

Authors

  • Darwin Lim Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON
  • Jonathan I. Izawa Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON
  • Paul Middlebrook The Grey-Bruce Health Services, Owen Sound, ON
  • Joseph L. Chin Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON

DOI:

https://doi.org/10.5489/cuaj.781

Abstract

Intravesical chemotherapy after transurethral resection of a bladder
tumour (TURBT) has been observed to significantly decrease
recurrence rates compared to TURBT alone. Though immediate
postoperative intravesical treatment with chemotherapeutic agents
after transurethral resection for superficial bladder carcinoma is
generally considered a safe and effective adjunctive therapy in
decreasing recurrence rates, its instillation is not always completely
innocuous. Lately, a more serious complication of bladder
perforation associated with immediate instillation of intravesical
mitomycin C (MMC) after TURBT was reported. We report
our own experience of a male patient with bladder perforation
after an early instillation of a single dose of MMC. In this case,
systemic toxicity occurred which required intensive care after
surgical repair.

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Author Biographies

Darwin Lim, Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON

Jonathan I. Izawa, Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON

Paul Middlebrook, The Grey-Bruce Health Services, Owen Sound, ON

Joseph L. Chin, Departments of Surgery & Oncology, Divisions of Urology & Surgical Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON

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How to Cite

Lim, D., Izawa, J. I., Middlebrook, P., & Chin, J. L. (2013). Bladder perforation after immediate postoperative intravesical instillation of mitomycin C. Canadian Urological Association Journal, 4(1), E1-E3. https://doi.org/10.5489/cuaj.781

Issue

Vol. 4 No. 1 (2010): CUAJ February

Section

Case Report

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