Systematic review of therapy for neurogenic detrusor overactivity

Authors

  • Clare J. Fowler Institute of Neurology, University College London, UK; Consultant, National Hospital for Neurology & Neurosurgery, London, UK

DOI:

https://doi.org/10.5489/cuaj.715

Abstract

While many neurologic diseases predispose patients to neurogenic
detrusor overactivity (NDO), the only populations that have been
systematically studied are adults with multiple sclerosis (MS), adults
with spinal cord injury (SCI) and children and young adults with
myelodysplasia. First-line pharmacotherapy for NDO is an antimuscarinic
drug. However, the evidence base for these agents in
this indication is poor. There is some high-quality evidence for the
efficacy of detrusor injections of botulinum toxin A in the treatment
of NDO, with significant reduction in urgency incontinence episodes,
improved urodynamic parameters, and improved quality of
life. While few adverse events have been reported with this therapy,
there is a need for intermittent self-catheterization in these groups.

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Author Biography

Clare J. Fowler, Institute of Neurology, University College London, UK; Consultant, National Hospital for Neurology & Neurosurgery, London, UK

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How to Cite

Fowler, C. J. (2013). Systematic review of therapy for neurogenic detrusor overactivity. Canadian Urological Association Journal, 5(5-S2), S146-S148. https://doi.org/10.5489/cuaj.715

Issue

Vol. 5 No. 5-S2 (2011): October

Section

Review

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