Systematic review of overactive bladder therapy in females
DOI:
https://doi.org/10.5489/cuaj.713Abstract
Although the prevalence of overactive bladder (OAB) is similarin both male and female populations, females have a greater tendency
to seek medical advice regarding their symptoms. A review
of the evidence of therapy among women shows that a variety of
modalities has been shown to be effective for symptom improvement
in women with OAB. Bladder retraining/re-education should
be considered for all women with OAB. With respect to first-line
pharmacotherapy with antimuscarinic agents, the development of
extended release preparations, bladder selective M3 antagonists
and alternative routes of delivery, have improved compliance and
persistence. Other pharmacotherapeutic options with potential for
providing benefit include antidepressants, vasopressin analogues,
alpha-adrenoceptor antagonists and beta-adrenoceptor agonists.
There are also a number of newer agents currently being investigated,
including calcium channel blocking agents, potassium channel
opening drugs, beta agonists and neurokinin receptor antagonists.
Intravesical injections of botulinum toxin may be an alternative,
while surgery can be considered for truly intractable cases.
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How to Cite
Cardozo, L. (2013). Systematic review of overactive bladder therapy in females. Canadian Urological Association Journal, 5(5-S2), S139-S142. https://doi.org/10.5489/cuaj.713
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