Pathophysiology of the lower urinary tract and CNS

Authors

  • Christopher Chapple Consultant Urological Surgeon, Sheffield Teaching Hospitals NHS Foundation Trust, Department of Urology, The Royal Hallamshire Hospital, Sheffield, UK

DOI:

https://doi.org/10.5489/cuaj.708

Abstract

A number of aspects of neural control are potentially important in
the control of bladder function, including both sensory and motor
and peripheral and central pathways. It is likely that a combination
of disorders of both central and peripheral neural mechanisms is
important in the genesis of urgency and the other symptoms of the
overactive bladder (OAB). Given the number of potential pathways
involved, potential pharmacologic targets for OAB exist in the CNS
(central nervous system; cerebral cortex, midbrain, spinal cord)
and periphery (LUT; lower urinary tract). Antimuscarinics are still
the mainstay of OAB treatment, but there are also a number of
other potentially efficacious drugs that may also provide benefit
against the neurologic components of OAB. This review discusses
the impact of neurological abnormalities on lower urinary tract
symptoms and the potential for treatments targeting these pathways
to improve symptoms.

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Author Biography

Christopher Chapple, Consultant Urological Surgeon, Sheffield Teaching Hospitals NHS Foundation Trust, Department of Urology, The Royal Hallamshire Hospital, Sheffield, UK

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How to Cite

Chapple, C. (2013). Pathophysiology of the lower urinary tract and CNS. Canadian Urological Association Journal, 5(5-S2), S126-S127. https://doi.org/10.5489/cuaj.708

Issue

Vol. 5 No. 5-S2 (2011): October

Section

Review

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