Segmental ureterectomy can be performed safely in patients with urothelial carcinoma of distal ureter

  • Zhuo Jia
  • Yan-Qing Gong
  • Cui-Jian Zhang
  • Zheng-Qing Bao
  • Xue-Song Li
  • Han Hao
  • Geng-Yan Xiong
  • Lei Zhang
  • Dong Fang
  • Zhi-Song He
  • Li-Qun Zhou
Keywords: Segmental ureterectomy, urothelial carcinoma

Abstract

Introduction: We aimed to compare oncological outcomes by surgery type (segmental ureterectomy [SU] vs. radical nephroureterectomy [RNU]) in a large cohort of patients with upper tract urothelial carcinoma (UTUC) of the distal ureter.

Methods: We performed a retrospective analysis of 219 patients with UTUC of the distal ureter among 931 patients with UTUC who underwent SU and RNU. Clinicopathological outcomes were evaluated. Cancer-specific survival (CSS), overall survival (OS), local recurrence-free survival (RFS), intravesical recurrence-free survival (IVRFS), contralateral recurrence-free survival, and distal metastasis-free survival were assessed by the Kaplan-Meier method and Cox regression, estimating hazard ratios (HR) and 95% confidence intervals (CIs).

Results: A total of 179 (81.7%) patients underwent RNU and 40 (18.3%) underwent SU: 85 males (47.5%) with RNU and 17 (42.5%) with SU (p=0.568). The median age with RNU and SU was 71 years (range 31–86) and 70 years (range 46–90), respectively (p=0.499). The T stage of the two groups did not differ (p=0.122), nor did mean tumor length (3.35±2.62 vs. 3.25±2.14; p=0.953), grade (p=0.075), tumor necrosis (p=0.634), or followup time (months) (58.1±8.1 vs. 63.7±3.4; p=0.462). The two groups did not differ in CSS (p=0.358) or OS (p=0.206), and surgery type did not predict CSS (HR 0.862; 95% CI 0.469–1.585; p=0.633) or OS (HR 0.764; 95% CI 0.419–1.392; p=0.379). Local RFS was higher with RNU than SU (96.2% vs. 86.0%; p=0.02), but the groups did not differ in IVRFS (p=0.661), contralateral RFS (p=0.183), or distant metastasis-free survival (p=0.078). On multivariate analysis, SU was associated with local RFS (HR 5.069; 95% CI 1.029–24.968; p=0.046) and distant metastasis-free survival (HR 6.497; 95% CI 1.196–35.283; p=0.03). Local RFS was lower with SU than RNU for patients with pT3–4 stage (p=0.006).

Conclusions: Long-term oncological outcomes were equivalent with SU and RNU in patients with UTUC of the distal ureter. SU affected local recurrence survival, especially with advanced tumor stage, and distant metastasis survival.

Published
2018-11-20
How to Cite
Jia, Z., Gong, Y.-Q., Zhang, C.-J., Bao, Z.-Q., Li, X.-S., Hao, H., Xiong, G.-Y., Zhang, L., Fang, D., He, Z.-S., & Zhou, L.-Q. (2018). Segmental ureterectomy can be performed safely in patients with urothelial carcinoma of distal ureter. Canadian Urological Association Journal, 13(7). https://doi.org/10.5489/cuaj.5555
Section
Original Research