Papillary renal cell carcinoma embedded in an oncocytoma: Case report of a rare combined tumour of the kidney

Authors

  • István Sejben Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
  • Zoltán Szabó Department of Urology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
  • Márta Loránd Department of Radiology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
  • Farkas Sükösd Department of Pathology, University of Szeged, Szeged, Hungary
  • Gábor Cserni Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary; and Department of Pathology, University of Szeged, Szeged, Hungary

DOI:

https://doi.org/10.5489/cuaj.414

Keywords:

papillary renal cell carcinoma, oncocytoma, immunohistochemistry, chromosome 7, chromosome 17, chromosome Y

Abstract

An asymptomatic 1-cm large papillary renal cell carcinoma (RCC) embedded in a 3.5-cm large oncocytoma was diagnosed and removed by right nephrectomy in a 68-year-old male investigated for the abdominal symptoms associated with cholelithiasis. The papillary RCC displayed positive immunohistochemical stainings with cytokeratin 7, alpha-methylacyl-CoA racemase and vimentin and was negative for the E-cadherin and CD117 immunostains, whereas the oncocytoma part showed opposite staining patterns. No gains of chromosomes 7 and 17 or loss of chromosome Y was detected in the papillary carcinoma by fluorescent in situ hybridization with centromeric enumeration probes. This finding is in keeping with the morphologic diagnosis of type 2 papillary RCC reported to have lower rates of these characteristic chromosomal changes. The combination of papillary RCC and oncocytoma, two tumours of different postulated origin, is extremely rare. It may represent a simple coincidence, but 2 previous cases and our current one share a few features, including the intimate embedment of the papillary RCC in the oncocytoma, the small size of the RCC and the old age of the patients. This case raises the point that renal oncocytomas can contain a hidden malignant tumour.

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Published

2013-07-02

How to Cite

Sejben, I., Szabó, Z., Loránd, M., Sükösd, F., & Cserni, G. (2013). Papillary renal cell carcinoma embedded in an oncocytoma: Case report of a rare combined tumour of the kidney. Canadian Urological Association Journal, 7(7-8), E513–6. https://doi.org/10.5489/cuaj.414

Issue

Vol. 7 No. 7-8 (2013): CUAJ July

Section

Case Report

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