The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer

  • Cihat Ozcan Ankara University School of Medicine
  • Onur Telli Ankara University School of Medicine
  • Erdem Ozturk Ankara University School of Medicine
  • Evren Suer Ankara University School of Medicine
  • Mehmet Ilker Gokce Ankara University School of Medicine
  • Omer Gulpinar Ankara University School of Medicine
  • Derya Oztuna Ankara University School of Medicine
  • Sumer Baltaci Ankara University School of Medicine
  • Cagatay Gogus Ankara University School of Medicine

Abstract

Introduction: We evaluated the prognostic effects of hematologic parameters of preoperative leukocytosis and neutrophil-to-lymphocyte ratio (NLR) in patients who underwent radical cystectomy for bladder cancer.

Methods: We retrospectively reviewed the medical records of 363 patients who underwent radical cystectomy for bladder cancer between January 1990 and June 2013. In total, 286 patients were included in the study. Age, gender, pathologic stage, lymph node involvement, preoperative hydronephrosis, histologic subtype, surgical margin status, and lymphovascular invasion were recorded for each patient. Univariate and multivariate analysis were performed to determine the prognostic value of the preoperative clinical and laboratory parameters on disease-specific survival (DSS). Additionally, the correlation between leukocytosis and other factors were evaluated.

Results: According to the univariate analysis preoperative leukocytosis and NLR were detected as negative prognostic factors on DSS. Preoperative leukocytosis, NLR, stage, lymph node involvement, histologic subtype, grade and age were independent prognostic factors for DSS, on multivariate analysis. Patients with leukocytosis had higher stage, grade and lymphovascular invasion.

Conclusions: Inexpensive, reproducible, and readily available peripheral blood count components of white blood cell count and NLR were independent prognostic factors, which can stratify DSS risks in bladder cancer patients who underwent radical cystectomy.

Author Biographies

Cihat Ozcan, Ankara University School of Medicine
Urology
Onur Telli, Ankara University School of Medicine
Urology
Erdem Ozturk, Ankara University School of Medicine
Urology
Evren Suer, Ankara University School of Medicine
UROLOGY
Mehmet Ilker Gokce, Ankara University School of Medicine
Urology
Omer Gulpinar, Ankara University School of Medicine
Urology
Derya Oztuna, Ankara University School of Medicine
Biostatistics and Informatics
Sumer Baltaci, Ankara University School of Medicine
Urology
Cagatay Gogus, Ankara University School of Medicine
Urology
Published
2015-11-04
How to Cite
Ozcan, C., Telli, O., Ozturk, E., Suer, E., Gokce, M. I., Gulpinar, O., Oztuna, D., Baltaci, S., & Gogus, C. (2015). The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer. Canadian Urological Association Journal, 9(11-12), E789-94. https://doi.org/10.5489/cuaj.3061
Section
Original Research