Mechanism of action of sacral nerve stimulation using a transdermal

Authors

  • Mohamed S. Elkelini S Elkelini Toronto Western Research Institute, Toronto, ON, Institute of Medical Science, University of Toronto and Department of Surgery, Division of Urology, University of Toronto, Toronto, ON
  • Igor Pravidivyi Toronto Western Research Institute, Toronto, ON
  • Magdy M. Hassouna Toronto Western Research Institute, Toronto, ON; Institute of Medical Science, University of Toronto and Department of Surgery, Division of Urology, University of Toronto, Toronto, ON

DOI:

https://doi.org/10.5489/cuaj.287

Abstract

Introduction: Sacral neuromodulation (SNM) is an effective treatment
modality for several urological problems, including neurogenic
bladder. However, the invasiveness of this technique makes
it unsuitable for many patients. We present a novel transdermal
amplitude-modulated signal (TAMS) that may provide a non-invasive
alternative to implantable SNM to treat neurogenic detrusor
overactivity (NDO).

Methods: In this study, we investigated the mechanism of action of non-invasive SNM using TAMS on our established spinal cord
injury (SCI) animal model. We demonstrated that spinally transected
rats develop urinary bladder hyper-reflexia after 3 weeks of SCI,
indicated by the presence of uninhibited contractions, increased
resting pressure, increased threshold pressure and increased maximum voiding pressure.

Results: Short-term neurostimulation affected urodynamics parameters by significantly reducing the threshold pressure (p = 0.02). Spinal transection also increased calcitonin gene-related protein
(CGRP) concentration in the L6 dorsal root ganglia; whereas,
neurostimulation significantly reduced CGRP concentration in L6
(p = 0.03).

Conclusion: TAMS caused a reduction in NDO by inhibiting
C-fibre activity.

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Published

2013-02-21

How to Cite

Elkelini, M. S. E. S., Pravidivyi, I., & Hassouna, M. M. (2013). Mechanism of action of sacral nerve stimulation using a transdermal. Canadian Urological Association Journal, 6(4), 227–30. https://doi.org/10.5489/cuaj.287

Issue

Vol. 6 No. 4 (2012): CUAJ August

Section

Original Research

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