Botulinum neurotoxin-A treatment of lower urinary tract symptoms in multiple sclerosis

Authors

  • Oussama El Yazami Adli Department of Urology, Jewish General Hospital, 3755 Côte Sainte-Catherine Road, Montreal, QC, Canada
  • Jacques Corcos Department of Urology, Jewish General Hospital, 3755 Côte Sainte-Catherine Road, Montreal, QC, Canada

DOI:

https://doi.org/10.5489/cuaj.1824

Abstract

Multiple sclerosis (MS) is the most common neuroinflammatory disease of the central nervous system and a leading cause of disability in young adults. Symptoms related to vesicourethral dysfunction are very prevalent, but not specific to underlying urodynamic abnormalities. Detrusor overactivity and detrusor external sphincter dysynergia are the most frequent findings and are usually linked. Botulinum neurotoxin-A injection represents a significant advance in the management of voiding dysfunction among MS patients failing first-line therapy. It significantly improves patients’ urodynamic parameters and quality of life, with efficacy sustained by repeated injections and minimal risk of adverse events.

Downloads

Download data is not yet available.

Downloads

Published

2014-01-14

How to Cite

El Yazami Adli, O., & Corcos, J. (2014). Botulinum neurotoxin-A treatment of lower urinary tract symptoms in multiple sclerosis. Canadian Urological Association Journal, 8(1-2), e61–67. https://doi.org/10.5489/cuaj.1824

Issue

Vol. 8 No. 1-2 (2014): CUAJ January

Section

Review

License

You, the Author(s), assign your copyright in and to the Article to the Canadian Urological Association. This means that you may not, without the prior written permission of the CUA:

  • Post the Article on any Web site
  • Translate or authorize a translation of the Article
  • Copy or otherwise reproduce the Article, in any format, beyond what is permitted under Canadian copyright law, or authorize others to do so
  • Copy or otherwise reproduce portions of the Article, including tables and figures, beyond what is permitted under Canadian copyright law, or authorize others to do so.

The CUA encourages use for non-commercial educational purposes and will not unreasonably deny any such permission request.

You retain your moral rights in and to the Article. This means that the CUA may not assert its copyright in such a way that would negatively reflect on your reputation or your right to be associated with the Article.

The CUA also requires you to warrant the following:

  • That you are the Author(s) and sole owner(s), that the Article is original and unpublished and that you have not previously assigned copyright or granted a licence to any other third party;
  • That all individuals who have made a substantive contribution to the article are acknowledged;
  • That the Article does not infringe any proprietary right of any third party and that you have received the permissions necessary to include the work of others in the Article; and
  • That the Article does not libel or violate the privacy rights of any third party.