Contemporary incidence and mortality rates of kidney cancer in the United States

Authors

  • Giorgio Gandaglia University of Montreal Health Center 1058, rue St-Denis, Montreal, QC, H2X 3J4, Canada Department of Urology, Vita Salute San Raffaele University, Milan, Italy
  • Praful Ravi West Middlesex University Hospital, London, United Kingdom
  • Firas Abdollah Department of Urology, Vita Salute San Raffaele University, Milan, Italy
  • Abd-El-Rahman M. Abd-El-Barr Vattikuti Urology Institute, Henry Ford Health Systems, Detroit, USA
  • Andreas Becker Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada Department of Urology, Prostate Cancer Center, University of Hamburg-Eppendorf, Hamburg, Germany
  • Ioana Popa Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada
  • Alberto Briganti Department of Urology, Vita Salute San Raffaele University, Milan, Italy
  • Pierre I Karakiewicz Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada Department of Urology, University of Montreal Health Center, Montreal, Canada
  • Quoc-Dien Trinh Department of Surgery, Division of Urology, Brigham and Women's Hospital / Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
  • Michael A Jewett Department of Surgical Oncology, Division of Urology, University Health Network, Toronto, Canada
  • Maxine Sun Cancer Prognostics and Health Outcomes Unit University of Montreal Health Center Montreal QC, Canada H2X1P1 Tel: 1-514-890-8000 ext: 35335 Fax: 1-514-227-5103

DOI:

https://doi.org/10.5489/cuaj.1760

Keywords:

kidney cancer, incidence, mortality, cancer-specific survival

Abstract

Introduction: This is a timely update of incidence and mortality for renal cell carcinoma (RCC) in the United States.

Methods: Relying on the Surveillance, Epidemiology, and End Results (SEER) database, we computed age-adjusted incidence, mortality rates and 5-year cancer-specific survival (CSS) for patients with histologically confirmed kidney cancer between 1975 and 2009. Long-term (1975–2009) and short-term (2000–2009) trends were examined by joinpoint analysis, and quantified using the annual percent change (APC). The reported findings were stratified according to disease stage.

Results: Age-adjusted incidence rates of RCC increased by +2.76%/year between 1975 and 2009 (from 6.5 to 17.1/100 000 person years, p < 0.001), and by +2.85%/year between 2000 and 2009 (p < 0.001). For the same time points, the corresponding APC for the incidence of localized stage were +4.55%/year (from 3.0 to 12.2/100 000 person years, p < 0.001), and +4.42%/year (p < 0.001), respectively. The incidence rates of regional stage increased by +0.88%/year between 1975 and 2009 (p < 0.001), but stabilized in recent years (2000–2009: +0.56%/year, p = 0.4). Incidence rates of distant stage remained unchanged in long- and short-term trends. Overall mortality rates increased by +1.72%/year between 1975 and 2009 (from 1.2 to 5.0/100 000 person-years, P<0.001), but stabilized between 1994 and 2004 (p = 0.1). Short-term mortality rates increased in a significant fashion by +3.14%/year only for localized stage (p < 0.001).

Interpretation: In contemporary years, there is a persisting upward trend in incidence and mortality of localized RCC.

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Published

2014-08-11

How to Cite

Gandaglia, G., Ravi, P., Abdollah, F., Abd-El-Barr, A.-E.-R. M., Becker, A., Popa, I., Briganti, A., Karakiewicz, P. I., Trinh, Q.-D., Jewett, M. A., & Sun, M. (2014). Contemporary incidence and mortality rates of kidney cancer in the United States. Canadian Urological Association Journal, 8(7-8), 247–52. https://doi.org/10.5489/cuaj.1760

Issue

Vol. 8 No. 7-8 (2014): CUAJ August

Section

Original Research

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