Seminal vesicle agenesis: An uncommon cause of azoospermia


  • Abderrazak Bouzouita
  • Walid Kerkeni
  • Hassine Abouda
  • Mohamed Khrouf
  • Hanene Elloumi
  • Najla Mnif
  • Taieb Messaoud
  • Amel Zhioua
  • Fethi Zhioua
  • Mohamed Chebil



agenesis, azoospermia, infertile men, seminal vesicle


Seminal vesicle malformations are a rare cause of obstructive azoospermia, often associated with other internal genitalia and upper urinary tract birth defects. We report 5 new cases of seminal vesicle agenesis in men presenting with hypospermia and azoospermia.Imaging showed seminal vesicle unilateral agenesis in all patients.The remaining seminal vesicle was hypoplastic in 3 cases, dilatedin 1 case and with abnormally thick content in another case. Vasdeferens agenesis was observed unilaterally in 2 patients and bilaterally in 2 other patients. No renal malformations were detected. Genetic study showed in all cases a 46 XY karyotype without any microdeletions. A single heterozygous cystic fibrosis transmembrane regulator gene mutation was diagnosed in 1 man, but not found in his partner. Intracytoplasmic sperm injection using sperm from a testicular biopsy was performed in 3 couples, without success.


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How to Cite

Bouzouita, A., Kerkeni, W., Abouda, H., Khrouf, M., Elloumi, H., Mnif, N., Messaoud, T., Zhioua, A., Zhioua, F., & Chebil, M. (2014). Seminal vesicle agenesis: An uncommon cause of azoospermia. Canadian Urological Association Journal, 8(3-4), e266–9.



Case Report