Simultaneous pancreas-kidney transplantation: The role in the treatment of type 1 diabetes and end-stage renal disease

Authors

  • Alex Tianxiang Jiang Western Univeristy
  • Neal Rowe Western University
  • Alp Sener Western University
  • Patrick Luke Western University

DOI:

https://doi.org/10.5489/cuaj.1597

Keywords:

simultaneous pancreas-kidney transplantation, type 1 diabetes mellitus, end-stage renal disease

Abstract

Type 1 diabetes mellitus (DM) is one of the most common and debilitating diseases to affect the world. Many patients are afflicted by microvascular and macrovascular complications, and succumb to end-stage renal disease (ESRD). Although dialysis and insulin therapy provides better glycemic control, it nonetheless significantly decreases a patient’s quality of life. Moreover, they cannot reverse ESRD or alleviate complications. Simultaneous pancreas-kidney (SPK) transplantation has revolutionized the way we manage type 1 DM; it provides a physiological means of achieving normoglycemia while rendering patients free of dialysis. Understanding this procedure is important because it is becoming a more common management strategy for patients with type 1 DM. In this review, we will begin with a brief summary of type 1 DM, followed by a comprehensive description of SPK procedure, including the history and technique. We will then present the outcomes of transplantation.

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Author Biographies

Alex Tianxiang Jiang, Western Univeristy

3rd year medical student; Department of Surgery, Division of Urology; Schulich School of Medicine and Dentistry, Western University

Neal Rowe, Western University

Transplant Fellow; Department of Surgery, Division of Urology; Multi-Organ Transplant Program, London Health Sciences Center; Western University

Alp Sener, Western University

Assistant Professor; Department of Surgery, Division of Urology; Multi-Organ Transplant Program, London Health Sciences Center; Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center; Department of Microbiology and Immunology; Center for Human Immunology; Western University

Patrick Luke, Western University

Professor; Department of Surgery, Division of Urology; Multi-Organ Transplant Program, London Health Sciences Center; Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center; Western University

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Published

2014-04-14

How to Cite

Jiang, A. T., Rowe, N., Sener, A., & Luke, P. (2014). Simultaneous pancreas-kidney transplantation: The role in the treatment of type 1 diabetes and end-stage renal disease. Canadian Urological Association Journal, 8(3-4), 135–8. https://doi.org/10.5489/cuaj.1597

Issue

Vol. 8 No. 3-4 (2014): CUAJ April

Section

Review

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