Investigating the effect of tamsulosin on the measurement of bladder wall thickness and International Prostate Symptom Score in benign prostatic hyperplasia

Authors

  • Kamyar Eghbali Department of Urology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
  • Mohammad Reza Shayegan Zakaria Research Center, Mashhad Branch, Islamic Azad University, Mashhad, Iran
  • Sina Kianoush Zakaria Research Center, Mashhad University of Medical Sciences, Faculty of Medicine, Mashhad, Iran

DOI:

https://doi.org/10.5489/cuaj.1244

Abstract

Introduction: According to previous studies, aging, gender, bladder volume and pathological states, such as bladder outflow obstruction, affect bladder wall thickness (BWT). The aim of this study was to evaluate the correlation between BWT and the International Prostatic Symptom Score (IPSS) in patients with benign prostatic hyperplasia (BPH) before and after tamsulosin treatment.

Methods: In this study, 60 BPH patients were included. After obtaining informed consent, data were gathered using questionnaires to determine IPSS. After that, prostate-specific antigen was measured and a clinical examination, including a digital rectal examination, was performed for all patients. BWT was determined by transabdominal ultrasound. Finally, all patients were treated with tamsulosin (0.4 mg/day) for 2 months. After completing treatment, the IPSS and BWT were measured again and compared with the initial findings.

Results: In total, 44 patients completed treatment. Patients aged 61.7 ± 9.2 years old. The mean ± standard deviation of IPSS and BWT were 14.6 ± 5.0 and 5.36 ± 1.28 mm before treatment, while they significantly (p < 0.0001) decreased to 8.2 ± 4.7 and 4.69 ± 1.23 mm, respectively, after treatment. Chi-square test showed that the decrease in BWT was significantly correlated with the improvement in IPSS (p = 0.002; r = 0.449).

Conclusion: After treatment with tamsulosin, patients experienced a reduction in their BWT which was significantly correlated with improvement in their IPSS. We conclude that transabdominal evaluation of BWT could be included in the follow-up assessment in BPH.

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Published

2013-05-13

How to Cite

Eghbali, K., Shayegan, M. R., & Kianoush, S. (2013). Investigating the effect of tamsulosin on the measurement of bladder wall thickness and International Prostate Symptom Score in benign prostatic hyperplasia. Canadian Urological Association Journal, 7(5-6), e317–21. https://doi.org/10.5489/cuaj.1244

Issue

Vol. 7 No. 5-6 (2013): CUAJ May

Section

Original Research

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