Perioperative chemotherapy for muscle-invasive bladder cancer
DOI:
https://doi.org/10.5489/cuaj.1202Abstract
Considerable debate exists concerning the combined use of systemicchemotherapy and radical surgery for muscle-invasive bladder
cancer. While there is evidence for a survival benefit after
neoadjuvant chemotherapy, the benefit is modest and the potential
toxicity and delay of time to surgery prior to cystectomy appears
to be deterring many surgeons from its administration. The evidence
for adjuvant chemotherapy, on the other hand, is less compelling
and substantial. Furthermore, the role of adjuvant compared
to salvage chemotherapy requires further investigation.
Similarly, research continues on identifying molecular and clinical
markers to best stratify patients for optimal perioperative therapy.
In this article, the evidence for radical cystectomy and
chemotherapy, given either in a neoadjuvant or adjuvant setting,
will be reviewed.
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How to Cite
Black, P., & So, A. (2013). Perioperative chemotherapy for muscle-invasive bladder cancer. Canadian Urological Association Journal, 3(6-S4), S223-S227. https://doi.org/10.5489/cuaj.1202
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