TY - JOUR AU - Fervaha, Gagan AU - Izard, Jason P. AU - Tripp, Dean A. AU - Aghel, Nazanin AU - Shayegan, Bobby AU - Klotz, Laurence AU - Niazi, Tamim AU - Fradet, Vincent AU - Taussky, Daniel AU - Lavallée, Luke T. AU - Hamilton, Robert J. AU - Brown, Ian AU - Chin, Joseph AU - Gopaul, Darin AU - Violette, Philippe D. AU - Davis, Margot K. AU - Karampatos, Sarah AU - Pinthus, Jehonathan H. AU - Leong, Darryl P. AU - Siemens, D. Robert PY - 2020/11/17 Y2 - 2024/03/29 TI - Psychological morbidity associated with prostate cancer: Rates and predictors of depression in the RADICAL PC study JF - Canadian Urological Association Journal JA - CUAJ VL - 15 IS - 6 SE - Original Research DO - 10.5489/cuaj.6912 UR - https://cuaj.ca/index.php/journal/article/view/6912 SP - 181-6 AB - <p><strong>Introduction:</strong> Across all cancer sites and stages, prostate cancer has one of the greatest median five-year survival rates, highlighting the important focus on survivorship issues following diagnosis and treatment. In the current study, we sought to evaluate the prevalence and predictors of depression in a large, multicenter, contemporary, prospectively collected sample of men with prostate cancer.</p><p><strong>Methods:</strong> Data from the current study were drawn from the baseline visit of men enrolled in the RADICAL PC study. Men with a new diagnosis of prostate cancer or patients initiating androgen deprivation therapy for prostate cancer for the first time were recruited. Depressive symptoms were evaluated using the nine-item version of the Patient Health Questionnaire (PHQ-9). To evaluate factors associated with depression, a multivariable logistic regression model was constructed, including biological, psychological, and social predictor variables.</p><p><strong>Results:</strong> Data from 2445 patients were analyzed. Of these, 201 (8.2%) endorsed clinically significant depression. Younger age (odds ratio [OR] 1.38, 95% confidence interval [CI] 1.16–1.60 per 10-year decrease), being a current smoker (OR 2.77, 95% CI 1.66–4.58), former alcohol use (OR 2.63, 95% CI 1.33–5.20), poorer performance status (OR 5.01, 95% CI 3.49–7.20), having a pre-existing clinical diagnosis of depression or anxiety (OR 3.64, 95% CI 2.42–5.48), and having high-risk prostate cancer (OR 1.49, 95% CI 1.05–2.12) all conferred independent risk for depression.</p><p><strong>Conclusions:</strong> Clinically significant depression is common in men with prostate cancer. Depression risk is associated with a host of biopsychosocial variables. Clinicians should be vigilant to screen for depression in those patients with poor social determinants of health, concomitant disability, and advanced disease.</p> ER -