TY - JOUR AU - Tripp, Dean A. AU - Mihajlovic, Valentina AU - Fretz, Katherine AU - Fervaha, Gagan AU - Izard, Jason AU - Corby, Rebecca AU - Siemens, D. Robert PY - 2020/05/12 Y2 - 2024/03/28 TI - Quality of life, depression, and psychosocial mechanisms of suicide risk in prostate cancer JF - Canadian Urological Association Journal JA - CUAJ VL - 14 IS - 10 SE - Original Research DO - 10.5489/cuaj.6310 UR - https://cuaj.ca/index.php/journal/article/view/6310 SP - E487-92 AB - <p><strong>Introduction:</strong> Prostate cancer (PCa) is the most common non-cutaneous cancer in men and is usually identified at a stage at which prolonged survival is expected. Therefore, strategies to address survivorship and promote well-being are crucial. This study’s aim was to better understand suicidal behavior in PCa patients by examining psychosocial mediators (i.e., depression, psychache, perceived burdensomeness [PB], thwarted belongingness [TB]) in the relationship between quality of life (PCa-QoL) and suicide risk.</p><p><strong>Methods:</strong> Four hundred and six men with PCa (Median age 69.35 years, standard deviation 7.79) completed an online survey on various psychosocial variables associated with suicide risk. A combined serial/parallel mediation model tested whether depression, in serial with both psychache and PB/TB, mediated the relationship between PCa-QoL and suicide risk.</p><p><strong>Results:</strong> Over 14% of participants’ self-reports indicated clinically significant suicide risk. Poorer PCa-QoL was related to greater depression, which was related to both greater psychache and PB/ TB, which was associated with greater suicide risk. The serial mediation effect of depression and psychache was significantly stronger than that of depression and PB/TB. PCa-QoL did not predict suicide risk through depression alone, showing that depressive symptoms affect suicide risk through psychache and PB/TB.</p><p><strong>Conclusions:</strong> Given the alarming estimate of individuals at risk for suicide in this study, clinicians should consider patients with poorer PCa-QoL and elevated depression for psychosocial referral or management. Psychache (i.e., psychological pain) and PB/TB (i.e., poor social fit) may be important targets for reducing suicide risk intervention beyond the impact of depression alone.</p> ER -