TY - JOUR AU - Aquil, Shahid AU - Sharma, Hemant AU - Alharbi, Bijad AU - Pacoli, Katharine AU - Luke, Patrick P. AU - Sener, Alp PY - 2019/02/26 Y2 - 2024/03/28 TI - The impact of a muscle pump activator on incisional wound healing compared to standard stockings and compression devices in kidney and kidney-pancreas transplant recipients: A randomized, controlled trial JF - Canadian Urological Association Journal JA - CUAJ VL - 13 IS - 11 SE - Original Research DO - 10.5489/cuaj.5822 UR - https://cuaj.ca/index.php/journal/article/view/5822 SP - E341-9 AB - <p><strong>Introduction:</strong> We aimed to evaluate the impact of thrombo-embolic- deterrent + intermittent pneumatic compression (TED + IPC) vs. muscle pump activator (MPA) on incisional wound healing in kidney and simultaneous pancreas-kidney (SPK) transplant recipients.</p><p><strong>Methods:</strong> We conducted a single-center, randomized, controlled trial in which 104 patients (kidney n=94; SPK n=10) were randomly assigned to wear TED + IPC (n=52) or MPA (n=52) for the first six days following surgery. Patient demographics, postoperative outcomes, and incisional wound images were taken using a Health Insurance Portability and Accountability Act (HIPAA)-compliant application on postoperative days (POD) 3, 5, and 30, and assessed using the validated Southampton Wound Care Score.</p><p><strong>Results:</strong> There were no demographic differences between the groups. The MPA group had a significant improvement in wound healing on POD 3 (p=0.04) that persisted until POD 5 (p=0.0003). At POD 30, both groups were similar in wound healing outcomes (p=0.51). Bayesian inferential analysis revealed that the use of TED + IPC following transplantation had inferior outcomes compared to the use of MPA with sequential moderate evidence. The rate of complex wound infections was significantly greater in the TED + IPC group compared to the MPA group (29% vs. 12%, respectively; p=0.03). Patients were more satisfied with the use of a MPA device than TED + IPC. No major complications were encountered in either group.</p><p><strong>Conclusions:</strong> The use of a MPA device in the immediate postoperative period leads to a significant improvement in immediate and early wound healing, and decreased number of complex wound infections following kidney and SPK transplantation compared to standard TED + IPC therapy. Patients were more satisfied with the use of a MPA device than TED + IPC.</p> ER -