@article{Ghavimi_Abdi_Waterhouse_Savdie_Chang_Harris_Machan_Gleave_So_Goldenberg_Black_2018, title={Natural history of prostatic lesions on serial multiparametric magnetic resonance imaging}, volume={12}, url={https://cuaj.ca/index.php/journal/article/view/4859}, DOI={10.5489/cuaj.4859}, abstractNote={<p><strong>Introduction:</strong> The natural history of prostatic lesions identified on multiparametric magnetic resonance imaging (mpMRI) is largely unknown. We aimed to describe changes observed over time on serial MRI.</p><p><strong>Methods:</strong> All patients with ≥2 MRI studies between 2008 and 2015 at our institution were identified. MRI progression was defined as an increase in Prostate Imaging Reporting and Data System (PI-RADS; version 2) or size of existing lesions, or the appearance of a new lesion PIRADS ≥4. Patients on active surveillance (AS) were analyzed for correlation of MRI progression to biopsy reclassification.</p><p><strong>Results:</strong> A total of 83 patients (54 on AS and 29 for diagnostic purposes) underwent serial MRI, with a mean interval of 1.9 years between scans. At baseline, 115 lesions (66 index, 49 non-index) were identified. Index lesions were more likely than non-index lesions to increase in size ≥2 mm (36.2 vs. 7.3%; p=0.002). Overall progression was more likely to be seen among the index cohort (34.8 vs. 7.6%; p<0.001). New lesions with PI-RADS ≥4 were seen on second imaging in 13 (16.5%) men, and became the index lesion in 29 cases (34.9%). Eighteen men on AS showed evidence of MRI progression (five with new lesions, 13 with progression of a previous lesion). Biopsy reclassification was present in three men (16.7%) with and seven men without MRI progression (19.4%).</p><p><strong>Conclusions:</strong> Overall changes in size and PI-RADS scores of index lesions on MRI were small. New lesions were common, but usually did not alter management.</p>}, number={8}, journal={Canadian Urological Association Journal}, author={Ghavimi, Samrad and Abdi, Hamidreza and Waterhouse, Jennifer and Savdie, Richard and Chang, Silvia and Harris, Alison and Machan, Lindsay and Gleave, Martin and So, Alan I. and Goldenberg, Larry and Black, Peter C.}, year={2018}, month={Mar.} }