@article{Billia_Siddiqui_Chan_Li_Al-Zahrani_Gomez_Chin_2016, title={Assessment of histopathological features of needle biopsy in recurrent prostate cancer following salvage high-intensity focused ultrasound}, volume={10}, url={https://cuaj.ca/index.php/journal/article/view/3918}, DOI={10.5489/cuaj.3918}, abstractNote={<p><strong>Introduction:</strong> Local recurrence of prostate cancer (PCa) following radiotherapy may be treated with curative intent using salvage highintensity focused ultrasound (s-HIFU). The interpretation of needle core biopsy specimens following s-HIFU is a daunting task, even for experienced pathologists. We describe various histopathological features encountered in biopsy specimens following whole-gland s-HIFU in one of the largest descriptive studies to date.</p><p><strong>Methods:</strong> Fifty-five patients with biopsy-proven localized radiorecurrent PCa underwent s-HIFU and transrectal ultrasound (TRUS)- guided prostatic needle biopsies at 180 days post-treatment. All biopsies were reviewed by two genitourinary pathologists.</p><p><strong>Results:</strong> PCa was detected in 11 (24%) biopsies. Radiation therapyassociated changes were identified in all cases. Additional findings included extensive coagulative stromal necrosis (100%), smudgy chromatin of cancer nuclei (82%), and markedly enlarged bizarre nuclei in the residual cancer (55%). Gleason grade assignment was possible in 10 (91%) of these biopsies and concordance of Gleason grading between pre- and post-therapy specimens was observed in six (60%) cases.</p><p><strong>Conclusions:</strong> The histological interpretation of needle biopsies following salvage HIFU is challenging and requires an understanding of the histopathological changes associated with this procedure in both tumoural and non-tumoural prostatic tissue. Accurate interpretation of the morphological changes following s-HIFU is instrumental for optimization of clinical decision-making and treatment planning in recurrent PCa.</p>}, number={11-12}, journal={Canadian Urological Association Journal}, author={Billia, Michele and Siddiqui, Khurram M. and Chan, Susanne and Li, Fan and Al-Zahrani, Ali and Gomez, Jose A. and Chin, Joseph L.}, year={2016}, month={Dec.}, pages={416–22} }