@article{Rosenzweig_Mor_Erlich_Laufer_Winkler_Kaver_Ramon_Dotan_2016, title={Urothelial-based reconstructive surgery for upper- and mid-ureteral defects: Long-term results}, volume={10}, url={https://cuaj.ca/index.php/journal/article/view/3659}, DOI={10.5489/cuaj.3659}, abstractNote={<p><strong>Introduction:</strong> Ureteral strictures can result in obstructive nephropathy and renal function deterioration. Surgical management of ureteral defects, especially in the proximal- and mid-ureter, is particularly challenging. Our purpose was to analyze the long-term outcomes of urothelial-based reconstructive surgery for upper- and mid-ureteral defects.</p><p><strong>Methods:</strong> We conducted a retrospective analysis of a single tertiary centre’s database, including 149 patients treated for ureteral defects between 2001 and 2011. Thirty-one patients (21%) underwent complex urothelial-based surgical repairs for upper- and mid-ureter defects. Patients’ median age was 61 years. The mean length of the ureteral strictures was 2.5 cm, located in upper-, mid-ureter, or in between in 19 (61%), 10 (32%), and two (6%) patients, respectively. All patients were treated with a primary urothelial-based repair. Median followup time was 26 months. The primary outcome of the study was the long-term preservation of renal function and lack of clinical obstruction. The secondary endpoint of the study was the assessment of the intra- and postoperative complication rates.</p><p><strong>Results:</strong> Most of the lesions were benign (22, 71%), while nine strictures (29%) were malignant. Seven patients (23%) suffered from postoperative complications, five of which were infectious. The median pre- and postoperative calculated glomerular filtration rates were 66 ml/min/1.72m2 and 64ml/min/1.72m2, respectively. Success rate was 84%, defined as lack of need for re-operation or kidney drainage at the last followup.</p><p><strong>Conclusions:</strong> Upper- and mid-ureteral defects present a complex pathology necessitating experienced reconstructive surgical skills. Our data suggest good long-term results for primary urothelialbased reconstructions for these pathologies.</p>}, number={9-10}, journal={Canadian Urological Association Journal}, author={Rosenzweig, Barak and Mor, Yoram and Erlich, Tomer and Laufer, Menachem and Winkler, Harry and Kaver, Issac and Ramon, Jacob and Dotan, Zohar A.}, year={2016}, month={Sep.}, pages={E290–5} }